Thursday, July 20, 2017

What & How of IUI-Intra-Uterine Insemination

Infertility IMSI ICSI IVF Donor Egg Treatement

Intrauterine insemination (IUI) is a fertility treatment that involves placing sperms inside a woman's uterus to facilitate fertilization. The goal of IUI is to increase the number of sperms that reach the fallopian tubes and subsequently increase the chance of fertilization.
IUI involves a laboratory procedure to separate motile sperms from sluggish or non-motile sperms . It can be performed with partner’s sperm or donor sperm (known as donor insemination). 

When is IUI recommended?
IUI can help one conceive if her partner has a low sperm count or poor sperm motility.
IUI also helps if the patient is taking medications to ovulate or produce extra eggs and insemination is timed to boost your chance of pregnancy.
Other fertility problems treatable with IUI include:
  • ·       Unexplained infertility, PCOD, Endometriosis,etc
  • ·       Cervical scarring or cervical mucus abnormalities
  • ·       Severe pain during intercourse
  • ·       Problems with ejaculation or developing an erection
  • ·       Sexually transmitted disease, such as HIV or hepatitis (in either partner)

How does IUI work?

IUI can only begin once it has been confirmed that the fallopian tubes are open and healthy. This will usually be checked through a tubal patency test by the fertility clinic.
Patient may undergo a hysterosalpingo-contrast sonography (HyCoSy) – which involves using a vaginal ultrasound probe to check the fallopian tubes for blockages – or a hysterosalpingogram, an x-ray of your fallopian tubes.
The timeline for IUI treatment usually is as follows:
  • ·       Egg production. The ovaries produce eggs for fertilization in a couple of ways. Your doctor may recommend an "unstimulated," or natural, IUI cycle, meaning no fertility drugs are used. Or a doctor may give you a fertility drug at the beginning of your period to stimulate the ovaries to produce several mature eggs. (Women typically release only one egg a month.)
  • ·    Tracking the eggs.Follicular study & monitoring is performed to figure out when ovulation occurs by doing an ultrasound.
  • ·      Washing the sperm. Once the patient ovulates, it's time for her partner to produce a sperm sample, which is then "washed." This process concentrates the sperms into a small amount of fluid. IUI can be done with sperms from the male partner or a donor, and can be combined with superovulation.
  • ·       Insemination. The doctor uses a thin, long tube (a catheter) to put the concentrated sperm directly into the uterus through the cervix. The procedure is usually painless, but sometimes  mild cramps are felt by the patient.This is generally a single insemination procedure which is performed post rupture of the follicles but some clinicians choose a double insemination per IUI cycle to improve the chances of success.
  • ·       Testing for pregnancy. A pregnancy test is done about two weeks after insemination.


  • Insemination combined with superovulation increases the risk of multiple pregnancy.
  • Insemination procedures pose a slight risk of infection.
  • Some women experience severe cramping during insemination.
  • There is a slight risk of ovarian hyperstimulation syndrome if superovulation is used together with insemination.

How successful is IUI?

The success of IUI depends on several factors. If a couple has the IUI procedure performed each month, success rates may reach as high as 30% per cycle depending on variables such as female age, duration of  infertility, and whether fertility drugs were used, among other variables.

While IUI is a less invasive and less expensive option, first-line treatment for couples with unexplained or male factor infertility.

Aditi Shirsat, M.Sc. 
Senior Embryologist with Corion Fertility Clinic.