Friday, June 16, 2017

Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) - To Help You Live Your Dream!

Comparison of Images used if IMSI & ICSI


Of a million sperms released in one ejaculation, a single sperm manages to fertilize the egg, which grows into an embryo and then a baby. Due to various reasons, when this does not happen, it is termed as infertility and is currently on the rise.

With In-vitro fertilization (IVF), couples sometimes go through multiple sessions to ensure fertilization. ICSI or intracytoplasmic sperm injection improved this chance of fertilization. It is where a single sperm is used to fertilize an egg in an artificially controlled environment and then injected into the uterus where it grows further.

The next step in this technique is IMSI, where the chances of successful pregnancy are further enhanced and also promises improved quality of the embryo. IMSI, as it stands for, has “morphologically selected” which means under a highly powerful microscope, the best sperms are selected and then used to fertilize the egg. Morphology stands for shape, and the shape of the sperm is a direct indicator of the sperm quality. This not just ensures good success rate but also ensures the sperm which is used produces a high-quality embryo.



Features
  • High success rate of fertility
  • Reliable and efficient method of ART (assisted reproductive technology)
  • More expensive than traditional IVF methods or ICSI
  • Requires complex equipment, training, and set-up
  • Useful in couples who have failed IVF previously
  • Male infertility with unidentifiable cause
  • Poor sperm quality
  • A screening is first done to decide if the sperms can be used directly
  • In case of hereditary diseases, a donor is preferred
  • The first technical step involves sperm collection, either directly or through a donor
  • Sperms are collected either through masturbation or through a small incision in the testicles
  • Sperms used could be fresh or frozen; fresh ones may be stored for later use also
  • The woman is put on some ovulation therapy to ensure the release of multiple eggs, so a good one is picked. These high doses of hormones ensure multiple eggs are released.
  • Egg release is monitored through blood and urine tests
  • They are collected within after 36 hours of release
  • A healthy egg is chosen and placed in a glass container containing hyaluronidase
  • Sperms are placed in a medium which will slow their movement, which enables picking a good sperm for fertilization
  • The dual advantage of this is that in addition to a high success rate of fertilization, the quality of the embryo is also assured 

Indications:
  1. Useful in couples who have failed IVF previously
  2. Male infertility with unidentifiable cause
  3. Poor sperm quality

What to expect?
Both partners are prepared both physically and mentally prior to IMSI.

Before the procedure - men:
  1. A screening is first done to decide if the sperms can be used directly
  2. In case of hereditary diseases, a donor is preferred
  3. The first technical step involves sperm collection, either directly or through a donor
  4. Sperms are collected either through masturbation or through a small incision in the testicles
  5. Sperms used could be fresh or frozen; fresh ones may be stored for later use also.

Before the procedure – women:
  1. The woman is put on some ovulation therapy to ensure the release of multiple eggs, so a good one is picked. These high doses of hormones ensure multiple eggs are released.
  2. Egg release is monitored through blood and urine tests
  3. They are collected within after 36 hours of release.

During the IMSI procedure:
  1. A healthy egg is chosen and placed in a glass container containing hyaluronidase
  2. Sperms are placed in a medium which will slow their movement, which enables picking a good sperm for fertilization
  3. The dual advantage of this is that in addition to a high success rate of fertilization, the quality of the embryo is also assured 

If you wish to discuss about any specific problem, you can consult a gynaecologist.

Tuesday, June 13, 2017

Know Everything About INVO - In-vitro fertilisation


In-vitro Fertilisation

INVO (intravaginal culture of oocytes), also called IVC (Intravaginal culture) is an abetted procedure of reproduction where early embryo development and oocyte fertilization are carried out inside a gas penetrable, air-free plastic tool or device that is placed into the maternal vaginal chamber for incubation. It is a device that helps the future mothers to participate in the evolution and growth of their own embryos present inside their body. The device is composed of an inner cavity with a protective outer rigid shell and a rotating valve.
It can be used for IVF (In Vitro Fertilization) cycles; whether with the mother's own eggs or any donor's eggs. It provides the same successful results as conventional treatments. It works in a very simple way:- when the requisite samples to produce embryos have been acquired or when the eggs have been impregnated in the laboratory, they together with culture medium are placed into the INVOcell device and then the device is inserted into the vagina of the mother and there it is kept for two to three days (for 72 hours culture period). Throughout this time, the mother can lead a practically normal life but she needs to elude taking bath, having intercourse or flying during those days on which she is wearing it.
When fertilisation takes place, it will be the mother's own heat which will supply the best conditions for the proper development of the embryos. Once they are set and ready, the doctor will remove the INVO from the mother's vagina to recover the embryos. The embryos are then evaluated under the microscope to choose the healthiest-looking ones to transfer them into the uterus. Within the uterus they will be embedded in order to begin developing.
Advantages of INVO are:
  1. It is one of the most cost-effective assisted conception treatments.
  2. In this method, the embryo incubation is more natural.
  3. Since in this whole process embryo incubation in the laboratory isn’t required, the possibility of stumbling at the laboratory is diminished.
  4. In this method, the couple experiencing the treatment is involved more.
  5. This method has similar efficacy as the IVF treatments.

Disadvantages of INVO are:

  • Since the device has to remain for three days in the mother's vagina, it causes some discomfort.
  • The patient has to spend much time in the assisted reproduction clinic and visit it more often.

The studies suggest that it could be a usable alternative choice for assisted reproduction. If you wish to discuss about any specific problem, you can consult a gynaecologist.