Friday, December 5, 2014

News : A Novel Role For Ranbp9 In Regulating Alternative Splicing In Spermatogenic Cells !!!

Highly expressed in the testis, a gene named Ranbp9 has been found to play a critical role in male fertility by controlling the correct expression of thousands of genes required for successful sperm production. A group of researchers led by Professor Wei Yan, at the University of Nevada School of Medicine has discovered that a loss of function of Ranbp9 leads to severely reduced male fertility due to disruptions in sperm development. A paper reporting this finding was published in PLOS Genetics on December 4, 2014.
Male infertility affects 1 out of 20 men of reproductive age worldwide and the underlying causes remain largely unknown. The production of functional sperm is a prerequisite for male fertility, and is achieved through a complex process termed spermatogenesis, which is controlled by numerous genes that are synthesized and processed into messenger ribonucleic acid (mRNA) molecules of different sizes. Disruptions of mRNA processing would lead to aberrant mRNA contents in the developing male germ cells, failed sperm production, and male infertility.
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Thursday, December 4, 2014

NEWS !!! Mutation Identified That Is Associated With Premature Ovarian Failure

Premature ovarian failure (POF) is estimated to affect 1-4% of the female population.
Women with POF can present with a variety of symptoms and many genes have been linked to this condition.
A new study in the Journal of Clinical Investigation identifies a specific mutation in a family that results in POF.
Aleksandar Rajkovic and colleagues at the University of Pittsburgh studied 3 sisters with POF-associated symptoms and identified and mutation in MCM8, a gene involved in chromosome maintenance.
Siblings without the MCM8 mutation did not have any signs of POF.
Cells from the affected sisters exhibited an inability to repair DNA damage.
The results of this study indicate that chromosomal instability may be a factor in the development of POF.
Title: Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability.


Tuesday, December 2, 2014

News : Researchers identify factors that may boost success of artificial insemination !!!

Artificial insemination, also referred to as intrauterine insemination (IUI), involves directly inserting sperm into a woman's uterus during ovulation. The aim of this procedure is to boost the chance of fertilization by increasing the number of sperm that reach the Fallopian tubes.

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