Monday, September 3, 2012

Recent Study : Full Chromosomal Testing Significantly Increases IVF Pregnancy Rates

One of the recent studies shows that full chromosomal testing Significantly increases IVF Pregnancy rates :

The results of the first randomized study into a form of Preimplantation Genetic Diagnosis (PGD) testing, 24Sure Array CGH (comparative genomic hybridization) technology, has found it significantly increases the pregnancy rates in IVF patients.

Published in May in the Journal of Molecular Cytogenetics, the American study found that 24Sure Array CGH technology delivers a 65% increase in pregnancy rates, even in younger patients with more favorable IVF outcomes.
Dr Leeanda Wilton, Scientific Director, Preimplantation Genetics for Melbourne IVF and IVF Australia welcomed the study, stating the results mirror the Advanced Embryo Selection successes.
Advanced Embryo Selection, using the 24Sure Array CGH technology, screens all 24 chromosomes in a developing embryo, which is a significant advance on earlier forms of PGD testing that only screened 8 out of 24 chromosomes.  A single cell is biopsied (removed) from the embryo on day three of development in the laboratory, and the DNA from the cell’s nucleus is multiplied thousands of times before being placed on a microarray, or DNA chip, where it is compared with normal male and female DNA. This allows the accurate detection of chromosome errors, increasing the chance of a healthy baby resulting from the transfer of a chromosomally normal embryo.
“Using Advanced Embryo Selection, testing can be performed on a single cell from a day 3 embyro, whereas similar forms of technology require embryos to develop to the blastocyst stage on day 5 in order for several cells to be available for testing,” Dr Wilton said.
“About 50% of all embryos fail to reach the blastocyst stage on day 5, and this means a number of patients have no embryos that can be tested.  Some of these embryos are viable and can result in live births.
“Advanced Embryo Selection also provides accurate results within 30 hours, meaning patients can undertake a fresh embryo transfer, and their treatment can continue uninterrupted, whereas in most cases embryos that need to be biopsied on day 5 must be frozen because the results are not available in time to perform a fresh embryo transfer.
Advanced Embryo Selection is most suited to couples or single women where:
  • 5 or more embryos have been replaced without success,
  • the woman is aged 38 or more
  • there is a history of recurrent miscarriage
  • there has been a previous pregnancy with a chromosome error e.g. Down syndrome
Study Reference:  The Journal of Molecular Cytogenetics by Yang et al 2012, 5:24 (2 May 2012)